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KMID : 0545120180280091554
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Journal of Microbiology and Biotechnology
2018 Volume.28 No. 9 p.1554 ~ p.1562
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Hepatitis E Virus Methyltransferase Inhibits Type I Interferon Induction by Targeting RIG-I
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Kang Sang-Min
Choi Chang-Sun
Choi In-Soo
Han Kwi-Nam
Roh Seong-Woon
Choi Jong-Sun
Kwon Joseph
Park Mi-Ju
Kim Seong-Jun
Myoung Jin-Jong
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Abstract
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The type I interferons (IFNs) play a vital role in activation of innate immunity in response to viral infection. Accordingly, viruses have evolved to employ various survival strategies to evade innate immune responses induced by type I IFNs. For example, HEV encoded papainlike cysteine protease (PCP) has been shown to inhibit IFN activation signaling by suppressing K63-linked de-ubiquitination of retinoic acid-inducible gene I (RIG-I) and TANK-binding kinase 1 (TBK1), thus effectively inhibiting down-stream activation of IFN signaling. In present study, we demonstrated that hepatitis E virus (HEV) inhibits poly inosinicpolycytidylic acid (poly(I:C))-induced IFN-β transcriptional induction. Moreover, by using reporter assay with individual HEV-encoded gene, we showed that HEV methyltransferase (MeT), a non-structural protein, significantly decreases RIG-I-induced IFN-β induction and NF-κB signaling activities in a dose-dependent manner. Taken together, we report here that MeT, along with PCP, is responsible for the inhibition of RIG-I-induced activation of type I IFNs, expanding the list of HEV-encoded antagonists of the host innate immunity.
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KEYWORD
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Hepatitis E virus, methyltransferase, RIG-I
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